Capelluto Research Group

Protein Signaling Domains Laboratory

Our laboratory employs biophysical approaches including high field nuclear magnetic resonance spectroscopy, circular dichroism, computer modeling, fluorescence spectroscopy, and surface plasmon resonance spectroscopy to determine ligand binding pockets and membrane insertion of protein domains from molecular to atomic resolution.

We validate our functional and structural approaches by using normal and disease-associated cell lines. With these tools we can establish how protein-ligand interactions control the function of proteins by modulating their subcellular localization.